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10.3390/pharmaceutics15020468 Summary Keywords melasma, hyperpigmentation, topical drug delivery, nanoparticles, nanotechnology, skin permeation, clinical effectiveness Citation Ghasemiyeh P, Fazlinejad R, Kiafar MR, Rasekh S, Mokhtarzadegan M and Mohammadi-Samani S (2024) Different therapeutic approaches in melasma: advances and limitations